In this episode of the Oncology Brothers podcast hosted by Rohit Gosain, MD and Rahul Gosain, MD speak to Jorge Cortes, MD, from the Georgia Cancer Center, joins to discuss the evolving treatment landscape for chronic myeloid leukemia (CML). The conversation covers risk stratification, treatment selection across TKI generations, monitoring strategies, and when to consider therapy discontinuation or transplant. The team also explores emerging data on asciminib, a promising third-generation TKI, and reviews key side effect profiles that shape clinical decisions. Packed with practical insights for community oncologists, this episode bridges academic advances with real-world care for patients living with CML.